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hydroxycarboxylic acid receptor 1

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Cat. No. Compare Product Name Species Source
  • HY-P702313
    HCAR2 Protein, Human (Cell-Free, His)

    hydroxycarboxylic acid receptor 2; G-protein coupled receptor 109A; G-protein coupled receptor HM74A; Niacin receptor 1; Nicotinic acid receptor

    		 Human E. coli Cell-free
    HCAR2 protein, a high-affinity receptor for nicotinic acid and (D)-beta-hydroxybutyrate, induces increased adiponectin secretion and reduced lipolysis through G(i)-protein-mediated adenylyl cyclase inhibition. This requires nicotinic acid doses exceeding typical dietary levels. HCAR2 also mediates nicotinic acid-induced apoptosis in neutrophils. Upon nicotinic acid activation, reduced cAMP levels potentially influence cAMP-dependent protein kinase A activity and target protein phosphorylation, leading to neutrophil apoptosis. Relative potency for displacing nicotinic acid binding: 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide. HCAR2 Protein, Human (Cell-Free, His) is the recombinant human-derived HCAR2 protein, expressed by E. coli Cell-free, with C-6*His labeled tag. The total length of HCAR2 Protein, Human (Cell-Free, His) is 363 a.a., with molecular weight of 42.7 kDa.

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